Biomechanics of arterial and venous wall

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Vítejte na stránkách Lukáše Horného, které jsou věnovány biomechanice srdečně cévního systému. Mojí prací je výzkum a vývoj konstitutivních modelů vhodných pro popis mechanického chování lidských krevních cév. Zejména se věnuji studiu materiálové nelinearity, anizotropie a vnitřní struktury. Účastním se řešení dvou grantů GA ČR (GA106/08/0557 Materiálové vlastnosti žil a jejich remodelace;  GAČR P108/10/1296 Vývoj a charakterizace aktivních hybridních textilií s integrovanými NiTi vlákny) a úkolů pro výzkumný záměr laboratoře (MSM6840770012 Transdisciplinární výzkum v oblasti biomedicínského inženýrství II). Vedu diplomové práce.

 

Latest...

April 2010           Opened topics for bachelor and master theses

1. Experimental analysis of strain field in arteries with digital image correlation
2. Mullins effect in arteries under multiaxial stress states
3. Damage and failure of blood vessel wall
4. Constitutive behavior of polymer tube reinforced with NiTi wires
 

 

January 2010     My two diploma students Eva Gultová (Diploma thesis: Mullins effect in blood vessels under cyclic loading) and Jan Veselý (Diploma thesis: Determination of constitutive parameters of venous wall) successffully defended their theses and will obtain Master degree.

 

Mullins Effect in Aorta and Limiting Extensibility Evolution

Mullins Effect in Aorta and Limiting Extensibility Evolution - obrázekMullins effect in aorta and limiting extensibility evolution.pdf, (234.68kB)

Mullinsův efekt v lidské aortě a vývoj limitní průtažnosti


Horný, L. - Gultová, E. - Chlup, H. - Kronek, J. - Sedláček, R. - et al.: Mullins Effect in Aorta and Limiting Extensibility Evolution. Bulletin of Applied Mechanics. 2010, vol. 6, no. 21, p. 1-5.

 

 

 

Cyclic uniaxial tensile tests with samples of human aorta were performed with an aim to obtain data describing the Mullins effect of arterial tissue. Due to presumed anisotropy of an aorta, reported widely, both samples oriented longitudinally and circumferentially were tested in each case. Every tested sample underwent cyclic tension limited to a certain value of a stretch four times, consecutively the limit of sustained deformation was increased and subsequent four cycles were performed. Significant stress softening of aortic tissue and residual strains were confirmed. An idealization was made in such a way that reloading and unloading curves are coincident.   It was hypothesized that the stress softening observed within reloading of previously loaded tissue may be described by an evolution of material parameters. These parameters should be related to an alternation of internal structure. The model based on changes in limiting fiber extensibility of fibrillar component of the aortic wall, primarily represented by a collagen, was proposed. The arterial wall was assumed to be hyperelastic transversely isotropic material with different response under primary loading and unloading. A stored energy function was additively split into isotropic and anisotropic part. Preferred direction in continuum, defined in referential configuration, was assumed to be unchanged with cyclic loading. Every straining level in the cyclic test had its own value of fiber extensibility. Explicit form of the relation between evolving limiting extensibility of fibers and maximum previously sustained deformation was proposed in such a way that limiting extensibility under primary loading is considered as the limit. The isotropic matrix response was modeled using Neo-Hooke term with shear modulus values different under primary loading and reloading, however all reloading values were held the same. The predictions of the model described above were in good agreement with observations.

Mechanical properties of artery-artery connection based upon transglutaminase cross-linked gelatin

Mechanical properties of artery-artery connection based upon transglutaminase cross-linked gelatin.pdf, (341.49kB)

Mechanické vlastnosti spoje tepna-tepna lepeného pomocí transglutaminázou síťované želatiny

J. Kronek, R. Žitný, L. Horný, H. Chlup, M. Beran (2010) Mechanical properties of artery-artery connection based upon transglutaminase cross-linked gelatin. Metalurgija 49(2):356-360.

 

The possibility of surgical repairing of blood vessels by biocompatible adhesive represents an alternative to the conventional sewing techniques. The aim of our study was to evaluate mechanical properties of arteries glued by a cross linked gelatin. Series of quasi-static uniaxial tensile tests of two overlapping arterial strips bonded by the two component glue (gelatin linked by the enzyme transglutaminase) was carried out. The 3D digital image correlation system gave local deformations, and thus the mutual slipping of the bonded strips could be evaluated. The effect of TGA and gelatin concentrations were estimated on the basis of observed data. Recorded maximum stresses were rather small (only tens of kPa). However, cross-linking activity on contact surfaces was proved histologically.

Constitutive modeling of coronary artery bypass graft with incorporated torsion

Constitutive modeling of coronary artery bypass graft with incorporated torsion.pdf, (221.92kB)

Konstitutivní model pro aorto-koronární bypass se zahrnutím zkrucování cévy

L. Horný, H. Chlup, R. Žitný, T. Adámek (2010) Constitutive modeling of coronary artery bypass graft with incorporated torsion. Metalurgija 49( 2):273-277.

  

The aim of this study is to describe mechanical response of coronary artery bypass graft (CABG). Attention was paid to sensitivity of a model to small torsions superimposed to an inflation and extension of an artery. The inflation-extension test was performed. A presence of torsions was proved via displacements analysis based on digital image correlation. CABG was modeled as nonlinearly hyperelastic, anisotropic and incompressible material with thin-walled cylindrical geometry. A strain energy function based on limiting fiber extensibility was used. Estimation of material parameters led to good agreement between the model and observations. It was concluded that the model is insensitive to small torsions superimposed to inflation-extension of the artery.

Computer-aided arterial architecture

CAAA WC09.pdf, (2.67MB)

Počítačová analýza vnitřní struktury lidské aorty

Papers presented in Munich on World Congress on Medical Physics and Biomedical Engineering 2009 September 7-12.

Second topic in Munich was computer-aided analysis of arterial architecture with particular attention paid to a collagen fibril orientation. We presented an algorithm based on binary representation of histological sections. The algorithm (rotating line segment) determines the direction most abundant in collagen. An empirical probability density function may also be obtained. Pdf file with poster presentation is available here. Details can be found as L. Horny, M. Hulan, R. Zitny, H. Chlup, S. Konvickova, and T. Adamek: Computer-Aided Analysis of Arterial Wall Architecture. in: O. Dössel and W C. Schlegel  (Eds.): WC 2009, IFMBE Proceedings 25/IV, pp. 1494-1497, 2009.

http://www.springerlink.com/content/r99rjjq7450650w8/

CABG constitutive model

CABG WC09.pdf, (1.47MB)

Konstitutivní chování aortokoronárního bypassu

Papers presented in Munich on World Congress on Medical Physics and Biomedical Engineering 2009 September 7-12.

A constitutive model based on hyperelastic theory of fiber reinforced materials with limiting fiber extensibility (Horgan, Saccomandi) and classical exponential model (Holzapfel, Gasser, Ogden) were utilized for human coronary artery bypass graft. This was the subject of my poster which is available in pdf. All the work may be found as L. Horny, H. Chlup, R. Zitny, S. Konvickova, and T. Adamek: Constitutive Behavior of Coronary Artery Bypass Graft. in: O. Dössel and W C. Schlegel  (Eds.): WC 2009, IFMBE Proceedings 25/IV, pp. 181–184, 2009.

http://www.springerlink.com/content/h381l71816454371/

Limiting fiber extensibility model was successfully fitted to inflation-extension test of human aorta. Details can be found in conference paper published in 4th European conference of IFMBE  http://www.springerlink.com/content/w7811xk5806q4481/
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22.12.2011 15:47: optimalizace webu pro vyhledávače

Experimental methods

Experimental methods - obrázekLatex tube and its material parameters estimation.pdf, (444.14kB)

Guide for experimental lecture in our laboratory. Students of Experimental Methods course perform inflation–extension test with latex tube to estimate its material parameters.

Limiting fiber extensibility utilized for venous wall

Limiting fiber extensibility utilized for venous wall - obrázekVenous wall limiting extensibility as damage parameter.ppt, (2.11MB)

Limiting fiber extensibility parameter captures an evolution of a constitutive equation within preconditioning. Venous wall as illustrative example. Report WASET Oct 2008 Venice.

Paper available on http://www.waset.org/pwaset/v34/v34-34.pdf

keywords: constitutive model, damage, fiber reinforced composite, hyperelasticity, limiting extensibility, vena cava

 

Constitutive equations for CABG

Constitutive equations for CABG - obrázekcoronary artery bypass graft.ppt, (4.71MB)

Constitutive equations for coronary artery bypass graft. Constitutive bahavior of vena saphena magna as graft material (3 years after surgery, thus 3 years of remodeling within arterial conditions). Report WASET Oct 2008 Venice.

Paper available on http://www.waset.org/pwaset/v34/v34-35.pdf

keywords: CABG, constitutive model, fiber reinforced composite, hyperelasticity, limiting extensibility, remodelation, strain energy

 

 
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